Daunorubicin HydrochlorideThird Party Manufacturing in India

Daunorubicin Hydrochloride works by binding directly to DNA to block the replication and division of leukemia cells.

The molecule intercalates between adjacent base pairs in the DNA double helix, which prevents the DNA from unwinding and halts both DNA and DNA-dependent RNA synthesis. Furthermore, it binds to and inhibits topoisomerase II, an enzyme crucial for repairing DNA tension during replication. By stabilizing the cleavage complex, it prevents DNA religation, leading to single and double-strand DNA breaks. Daunorubicin also triggers the intracellular generation of reactive oxygen species (free radicals), which damages the cell membrane and DNA structure, inducing apoptosis.

Unlike typical antimetabolites, Daunorubicin Hydrochloride is an anthracycline antibiotic that kills cells in multiple phases of the cell cycle, though it is most active during the S-phase. It is highly effective for inducing remission in pediatric and adult leukemia patients.

Daunorubicin Hydrochloride (CAS 23541-50-6) is a vital anthracycline chemotherapy agent widely utilized in hematological oncology. Celesta offers premier services for Daunorubicin Hydrochloride third party manufacturing in India, supplying high-quality oncology injectables to global markets.

Therapeutic Uses

Daunorubicin Hydrochloride is prescribed for the treatment of:

• Acute Myelogenous Leukemia (AML): Used as a first-line induction chemotherapy agent in adults, often in combination with cytarabine.
• Acute Lymphoblastic Leukemia (ALL): Indicated for remission induction in both pediatric and adult ALL cell lines.
• Chronic Myelogenous Leukemia (CML): Used in specific chemotherapy protocols during blast crisis or when other therapies fail.

Choosing a Daunorubicin Hydrochloride Manufacturer in India

Daunorubicin Hydrochloride is listed as an essential medicine by the WHO, reflecting its critical role in leukemia therapy. Because it is a highly cytotoxic anthracycline, its production requires dedicated cytotoxic manufacturing facilities, isolated aseptic filling areas, and lyophilization equipment. Sourcing from a WHO-GMP certified manufacturer in India ensures compliance with strict environmental controls to prevent cross-contamination and protect workers. Sourcing through a WHO-GMP certified partner ensures high-quality sterile products that meet IP, BP, and USP monographs, which is essential for national health tenders and global export channels.

To place an order or discuss customization, please contact our team. You can view all our oncology injectables on our manufacturing listing or learn about our service offerings on our contract manufacturing page.

This makes Daunorubicin Hydrochloride one of the most sought-after molecules for third party manufacturing in India, with consistent demand from cancer hospitals and export-oriented distributors.