AciclovirThird Party Manufacturing in India

Aciclovir works by selectively inhibiting the replication of viral DNA.

It is a synthetic purine nucleoside analogue that requires activation by the viral enzyme thymidine kinase, converting it into aciclovir monophosphate. Host cellular enzymes then convert it into its active triphosphate form. This active form competitively inhibits viral DNA polymerase and incorporates itself into the growing viral DNA chain, leading to premature chain termination and stopping viral replication.

Unlike broader antivirals, Aciclovir is highly specific to cells infected with herpes viruses, minimizing toxicity to normal human cells. It is highly effective and well-tolerated for patients managing Herpes Simplex and Varicella Zoster infections.

Therapeutic Uses

Aciclovir is prescribed for the treatment of:

• Herpes Simplex Virus (HSV): Treats genital herpes, cold sores, and herpes encephalitis.
• Varicella Zoster Virus (VZV): Manages chickenpox and shingles (herpes zoster), reducing severity and duration.
• Prophylaxis: Prevents viral reactivation in immunocompromised patients, such as those undergoing chemotherapy or organ transplants.

Why Manufacturers Choose Aciclovir

Aciclovir remains the gold standard antiviral for common herpes virus infections globally. Its safety profile allows for widespread use across multiple formulations, including topical creams, oral tablets, and intravenous infusions for severe cases.

This makes Aciclovir a highly sought-after molecule for third party manufacturing in India, with immense demand from both domestic dermatology franchises and international export markets.