Cefepime Hydrochloride + Sulbactam SodiumThird Party Manufacturing in India

Cefepime Hydrochloride + Sulbactam Sodium (CAS 123171-59-5 & CAS 69388-84-7) works through a dual mechanism that combines a powerful fourth-generation cephalosporin antibiotic with a potent beta-lactamase inhibitor. Cefepime Hydrochloride acts by binding to and inactivating penicillin-binding proteins on the inner membrane of the bacterial cell wall. This binding inhibits transpeptidation, the final step in the synthesis of the peptidoglycan layer, which destabilizes the bacterial cell wall and leads to osmotic lysis and bacterial death. Sulbactam Sodium acts as a beta-lactamase inhibitor. While it has limited intrinsic antibacterial activity, it binds irreversibly to beta-lactamase enzymes produced by resistant bacterial strains. This binding prevents these enzymes from degrading cefepime, restoring and expanding the antibiotic's spectrum of activity against beta-lactamase-producing organisms. Unlike standard monotherapy, this combination effectively overcomes drug-resistance mechanisms, particularly in Gram-negative bacteria. It is highly effective for patients suffering from severe nosocomial infections where multi-drug resistant pathogens are suspected. The combination shows excellent activity against Pseudomonas aeruginosa, Enterobacteriaceae, and Acinetobacter species.

We provide specialized production lines for Cefepime + Sulbactam third party manufacturing in India, supplying high-quality critical care antibiotics to global markets. Cefepime Hydrochloride and Sulbactam Sodium (CAS 123171-59-5 & CAS 69388-84-7) injection is a key combination product used to combat multi-drug resistant Gram-negative infections.

Therapeutic Uses

Cefepime Hydrochloride + Sulbactam Sodium injection is prescribed for severe bacterial infections, including:

• Nosocomial Pneumonia: Hospital-acquired and ventilator-associated pneumonia caused by drug-resistant Gram-negative pathogens.
• Complicated Urinary Tract Infections: Severe kidney and urinary tract infections, including pyelonephritis.
• Complicated Intra-Abdominal Infections: Deep abdominal infections, peritonitis, and post-surgical abscesses, often in combination with anaerobic coverage.
• Bacterial Septicemia: Used as an empirical or targeted treatment for systemic bloodstream infections.
• Empiric Therapy for Febrile Neutropenia: Initial treatment in neutropenic patients presenting with unexplained fever.

Finding a Cefepime + Sulbactam Manufacturer

As antibiotic resistance increases, hospital supply chains require a reliable Cefepime + Sulbactam manufacturer to fulfill clinical demand. Dry powder antibiotic combinations are highly specialized, requiring dedicated facilities to prevent contamination.

Our manufacturing partners utilize WHO-GMP certified aseptic powder-filling blocks. We offer Cefepime 1g + Sulbactam 500mg (1.5g) dry powder vials manufactured under strict WHO-GMP certified standards. This ensures high purity and stability, making it an excellent addition to a B2B contract manufacturing or PCD franchise portfolio.