Paracetamol + Cetirizine Hydrochloride + Phenylephrine + Dextromethorphan HydrobromideThird Party Manufacturing in India

Paracetamol + Cetirizine Hydrochloride + Phenylephrine + Dextromethorphan Hydrobromide is a comprehensive multi-ingredient syrup designed to address all major symptoms of the common cold and flu through four distinct pharmacological mechanisms.

Paracetamol provides centrally acting analgesic and antipyretic activity by inhibiting cyclooxygenase enzymes in the brain, reducing prostaglandin synthesis and thereby alleviating fever, headache, and generalized body aches that commonly accompany colds and influenza. Cetirizine Hydrochloride is a long-acting, second-generation antihistamine that selectively blocks peripheral histamine H₁ receptors. By preventing histamine from binding to these receptors, it effectively reduces sneezing, rhinorrhoea, nasal itching, and watery eyes without significant sedation. Phenylephrine is a selective alpha-1 adrenergic receptor agonist that produces vasoconstriction in the nasal mucosa, relieving nasal congestion, sinus pressure, and improving airflow. Dextromethorphan Hydrobromide acts centrally on the cough center in the medulla oblongata, raising the threshold for coughing. It is a non-opioid antitussive that suppresses both dry and irritating cough by binding to NMDA receptors and sigma-1 receptors in the brainstem.

This four-component combination provides comprehensive symptomatic relief from fever, nasal congestion, sneezing, cough, and body aches in a single convenient syrup formulation.

Therapeutic Uses

Paracetamol + Cetirizine Hydrochloride + Phenylephrine + Dextromethorphan Hydrobromide Syrup is indicated for the symptomatic relief of multiple symptoms associated with the common cold, influenza, and upper respiratory tract infections:

• Fever and Body Aches: Paracetamol reduces elevated body temperature and relieves headache, myalgia, and arthralgia associated with febrile illness.
• Nasal Congestion: Phenylephrine provides effective decongestion of the nasal passages, relieving stuffy nose, sinus pressure, and breathing difficulty.
• Sneezing and Runny Nose: Cetirizine blocks histamine-mediated allergic and cold symptoms including sneezing, rhinorrhoea, nasal itching, and watery eyes.
• Cough: Dextromethorphan suppresses both dry and irritating cough by raising the cough threshold in the brainstem.
• Allergic Rhinitis with Cold Symptoms: Useful when allergic symptoms like sneezing coexist with infectious cold symptoms.

Why Manufacturers Choose Paracetamol + Cetirizine + Phenylephrine + Dextromethorphan

This four-component cold and flu syrup is one of the most comprehensive over-the-counter cough and cold formulations available. It covers the full spectrum of cold symptoms making it a first-line recommendation for pharmacists and physicians. Indian contract manufacturers benefit from the ready availability of all four APIs in the domestic market, well-established formulation science for liquid oral preparations, and compatibility with high-speed syrup filling lines. The product commands strong demand during flu seasons and is exported extensively to Africa, Southeast Asia, the Middle East, and CIS countries. For PCD franchise operators, this syrup offers a complete cold management solution under their own brand name with broad symptom coverage ensuring consistent recommendation across all age groups.