Paracetamol + Promethazine Hydrochloride + IbuprofenThird Party Manufacturing in India

Paracetamol, Promethazine Hydrochloride, and Ibuprofen work by providing a comprehensive, multi-modal approach to pain, inflammation, and accompanying distress.

Paracetamol acts centrally to block prostaglandin synthesis, elevating the pain threshold and reducing fever. Ibuprofen, a potent NSAID, acts peripherally by inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes, which halts the production of inflammatory mediators directly at the site of tissue injury. Promethazine Hydrochloride acts as an H1-receptor antagonist and possesses strong central sedative and antiemetic properties, which alleviate the restlessness, nausea, and allergic responses often associated with severe pain or illness.

Unlike single-agent therapies, this robust combination synergistically controls pain, dramatically reduces inflammation, and ensures patient comfort. It is highly effective for severe acute symptomatic relief.

Therapeutic Uses

This powerful combination of Paracetamol, Promethazine Hydrochloride, and Ibuprofen is prescribed for the treatment of:

• Severe Acute Pain: Provides rapid relief from intense musculoskeletal pain, post-surgical pain, and severe headaches.
• Inflammatory Conditions with Fever: Effectively manages high fever that is accompanied by inflammatory symptoms and body aches.
• Pain with Nausea or Restlessness: Particularly useful when severe pain is complicated by nausea, vomiting, or significant patient distress, thanks to the antiemetic properties of Promethazine.

Why Manufacturers Choose This Combination

Combining three potent active pharmaceutical ingredients into a stable liquid dosage form is a complex process. This specialized formulation sees robust demand in the Indian domestic market for its fast-acting symptomatic relief.

It stands out in PCD franchise portfolios as a premium analgesic offering. Our WHO-GMP certified facilities utilize advanced formulation technologies to ensure uniform dispersion, excellent palatability, and extended shelf life for this multi-component medication.