Tranexamic Acid + Mefenamic AcidThird Party Manufacturing in India

Tranexamic Acid + Mefenamic Acid is a synergistic fixed-dose combination that addresses both excessive bleeding and pain through complementary pharmacological mechanisms.

Tranexamic Acid, an antifibrinolytic, works by competitively blocking the lysine-binding sites on plasminogen molecules. This prevents the conversion of plasminogen to plasmin, stabilizing fibrin clots and reducing fibrinolysis. By preserving clot integrity, it effectively controls bleeding in conditions such as menorrhagia and post-surgical hemorrhage.

Mefenamic Acid is a non-steroidal anti-inflammatory drug belonging to the fenamate class. It inhibits both cyclooxygenase enzymes COX-1 and COX-2, blocking the conversion of arachidonic acid to prostaglandins and thromboxanes at peripheral sites of inflammation. This reduces pain and inflammation associated with prostaglandin-mediated conditions. Mefenamic acid also directly antagonizes certain prostaglandin receptors and may modulate GABA-A receptors, contributing to its analgesic effects beyond simple COX inhibition.

The combination is particularly valuable in dysmenorrhoea and menorrhagia, where both heavy bleeding and painful cramping need simultaneous management. Tranexamic acid reduces menstrual blood loss while mefenamic acid alleviates the associated pelvic pain and inflammation.

Therapeutic Uses

Tranexamic Acid + Mefenamic Acid combination is prescribed for:

• Menorrhagia with Dysmenorrhoea: Simultaneously reduces heavy menstrual bleeding and relieves painful menstrual cramps. Tranexamic acid decreases blood loss while mefenamic acid targets prostaglandin-mediated pelvic pain.
• Postpartum Bleeding with Afterpains: Controls obstetric hemorrhage while managing uterine cramping during the postpartum period.
• Intrauterine Device (IUD)-Related Bleeding: Manages breakthrough bleeding and cramping associated with copper and hormonal IUDs.
• Dysfunctional Uterine Bleeding: Provides symptom control in women with abnormal uterine bleeding without organic pathology.
• Post-Surgical Gynecological Bleeding: Reduces blood loss and pain following procedures such as polypectomy, endometrial ablation, and cervical surgeries.
• Dental Procedures with Inflammation: Controls bleeding and postoperative discomfort in patients undergoing oral surgery.

Why Manufacturers Choose Tranexamic Acid + Mefenamic Acid

This combination addresses two of the most common complaints in gynecological practice heavy bleeding and pelvic pain creating a large and stable addressable market. Both active pharmaceutical ingredients have extensive safety records, well-established manufacturing processes, and reliable supply chains with multiple domestic API sources in India.

This makes Tranexamic Acid + Mefenamic Acid an attractive formulation for third party manufacturing in India, with consistent demand from PCD franchise partners targeting the women's health segment.