I TRANS 4.5 INJ
Composition:Each vial contains: Piperacillin 4 gm Tazobactam 0.5 gm
| Composition | Composition:Each vial contains: Piperacillin 4 gm Tazobactam 0.5 gm |
| Packing | VIAL WITH SWFI - 1 VialPack Style: Vial |
| MRP | ₹419 |
Product Overview
I TRANS 4.5 INJ is a premier, broad-spectrum injectable antibiotic combination designed for intensive hospital care settings. It provides excellent empirical coverage against both Gram-positive and Gram-negative aerobic and anaerobic organisms, including Pseudomonas aeruginosa.
Indications
Clinically indicated for the empirical or targeted management of serious infections:
- Nosocomial and community-acquired severe pneumonia.
- Complicated intra-abdominal infections and skin structure infections (including diabetic foot infections).
- Complicated urinary tract infections and febrile neutropenia in adult patients.
Dosage & Administration
Administered via intravenous infusion over a 30-minute period. The standard adult dose is 4.5g every six hours, totaling 18g per day. Renal dosage adjustments are required for patients with a creatinine clearance less than 40 mL/min.
Adverse Effects
Common adverse effects include diarrhea, nausea, vomiting, skin rash, pruritus, headache, insomnia, and transient alterations in liver enzymes or white blood cell counts.
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Contraindications
Absolute contraindication in patients with a history of allergic reactions to any penicillin, cephalosporin, or beta-lactamase inhibitor.
Warnings & Precautions
Serious and occasionally fatal hypersensitivity reactions have been reported. Perform periodic assessments of hematopoietic, renal, and hepatic functions during prolonged courses of treatment.
Drug Interactions
Concurrent use with tobramycin or other aminoglycosides may result in mutual inactivation (avoid mixing in the same bag). Can increase the half-life of methotrexate and prolong the neuromuscular blockade of vecuronium.
Storage Instructions
Store unconstitutioned powder vials below 25°C. Discard any unused portion of the reconstituted solution after the recommended structural stability window.
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